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结合富含生长因子的等离子体与不同的骨移植对早期骨愈合的影响:一项实验研究

Metehan Keskin, Mehmet Cihan Bereket, Nilüfer Özkan

The International journal of oral & maxillofacial implants

|June 6, 2023

概括

将富含生长因子 (PRGF) 的血添加到像自移植,DFDBA和DBBM这样的骨移植中,可显著增强早期骨形成并加速组织重塑. 与单独使用的移植相比,这改善了骨化.

科学领域:

再生医学是一种再生医学.
生物材料科学是生物材料的科学.
口腔和大面部外科手术

背景情况:

骨再生对于口腔和大面部重建至关重要.
生长因子在骨愈合和骨化中起着至关重要的作用.
富含生长因子 (PRGF) 的血是自身生长因子的缩来源.

研究的目的:

研究结合富含生长因子 (PRGF) 的血与骨移植对早期骨化造成的组织学和放射学影响.
评估PRGF对骨形成和组织重塑的影响,当与自体移植,非矿物化冷干燥骨移植 (DFDBA) 和脱蛋白牛骨矿物质 (DBBM) 一起使用时.

主要方法:

使用了12只新西兰雄,分为对照组和实验组.
对照组接受了单独的自移植,DFDBA或DBBM.
实验小组接受了自移植+PRGF,DFDBA+PRGF,或DBBM+PRGF. 这三种组分分别是:
骨,连接组织和毛细血管体积的立体评估,以及放射性骨密度评估,在28天后进行.

主要成果:

与对照组相比,实验组的骨和毛细血管体积显著增加.
在实验组中,结缔组织体积显著下降 (P < .001).
实验组的放射性骨密度更高,在DFDBA + PRGF和单独的DFDBA之间发现了统计学上显著的差异 (P < .011).

结论:

在自移植,DFDBA和DBBM中添加PRGF,与单独使用的移植相比,可以增强早期骨质生成.
在缺陷内,PRGF加速了连接组织重塑为骨的过程.
这种组合疗法有望改善骨再生结果.

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