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新生儿不同程度的缺氧缺血脑病变的功能性大脑网络的变化
Yingying Wang1, Yi Wang2, Guowei Hua1
1Department of Neonatology, Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.
Brain connectivity
|June 6, 2023
概括
新生儿中适度至严重的缺氧缺血性脑病变 (HIE) 与轻度的HIE相比,与大脑功能连接性降低有关. 这会影响受影响婴儿的情绪处理,感官运动技能和认知功能.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 医疗成像医学成像
背景情况:
- 新生儿缺氧缺血性脑病变 (HIE) 是全球新生儿死亡率和长期残疾的主要原因.
- 关于使用休息状态功能磁共振成像 (rs-fMRI) 来研究HIE儿童的大脑发育的研究有限.
研究的目的:
- 使用rs-fMRI调查不同程度的HIE新生儿脑功能变化的研究.
- 为了比较轻度和中度至重度的HIE组之间的功能性大脑网络连接.
主要方法:
- 在2018年2月至2020年5月期间招募了44名HIE患者 (21人轻度,23人中度/重度).
- 使用了传统和功能性MRI扫描.
- 应用低频波动的振幅和大脑网络边缘分析.
主要成果:
- 中度至重度HIE组显示功能连接性显著降低.
- 连接性下降的关键区域包括右补充运动区域和右前中心,右语言和右海马,左皮质和右桃体,右皮质和右后带状皮质之间的连接.
- 这些减少在统计学上是显著的 (p < 0.001,未经校正).
结论:
- 患有中度至重度HIE的婴儿与患有轻度HIE的婴儿相比,表现出明显的脑功能连接改变模式.
- 研究结果表明,中度至重度HIE新生儿在情绪处理,感官运动技能,认知功能和学习/记忆方面的发展滞后.
- rs-fMRI是评估HIE中大脑功能的一个有价值的工具.
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