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Updated: Jul 27, 2025

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一个专门的整合素结合基因使得proTGF-β2能够通过整合素αVβ6激活,但不能通过αVβ8激活

Viet Q Le1,2, Bo Zhao1,2, Siddanth Ramesh1

  • 1Program in Cellular and Molecular Medicine, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|June 6, 2023
PubMed
概括

转化生长因子-β2 (TGF-β2) 激活是由一个新的整蛋白结合动机介导的,与TGF-β1和β3不同. 这种动图特别涉及整合素αVβ6,影响纤维化治疗.

关键词:
在X射线晶体学.整合物是一种整合物.转化增长因子β转化增长因子β.在TGFb2上.

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