认知储备可以缓解多发性硬化症中疲劳和抑郁症状的影响
Megan L Bradson1, Margaret H Cadden2, Kaitlin E Riegler1,3
1Department of Psychology, The Pennsylvania State University, University Park, PA, USA.
概括
认知储备可以防止多发性硬化症 (MS) 中的抑郁症. 高认知储备 (CR) 防止疲劳导致MS患者的抑郁症状,这表明CR是管理MS的关键因素.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 临床医学 临床医学
背景情况:
- 疲劳和抑郁症状在多发性硬化症 (MS) 中很常见.
- 在MS中疲劳和抑郁之间的关系可能受到认知储备 (CR) 的影响.
研究的目的:
- 检查多发性硬化症 (PwMS) 患者的认知储备 (CR) 作为疲劳和抑郁症状之间的调节者.
主要方法:
- 53名PwMS完成了神经心理测试和关于疲劳和抑郁症状的问卷.
- 认知储备 (CR) 用固定CR (教育,先发病的智力) 和可塑性CR (认知力,运动,社交) 来评估.
- 回归分析探讨了疲劳,CR和抑郁症状之间的相互作用,使用邦费罗尼校正 (p < .01).
主要成果:
- 在疲劳和固定CR (p = .005) 和可变CR (p = .004) 之间发现了显著的相互作用.
- 疲劳仅在PwMS中预测抑郁症状,具有较低的固定或可形CR (p < .001).
- 在PwMS中没有观察到疲劳和抑郁之间的显著关系,具有高固定或可形CR (p > .01).
结论:
- 认知储备 (CR) 显著缓解了MS患者疲劳和抑郁症状之间的联系.
- 高度的认知储备 (固定或可形) 可能缓冲MS中与疲劳相关的抑郁症状的发展.
- 保持或增强认知储备可能是减轻MS疲劳的个体抑郁风险的策略.
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