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在一个ex vivo牛肌病模型中的双频沸性组织

Molly Smallcomb¹, Julianna C Simon¹

¹Graduate Program in Acoustics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

The Journal of the Acoustical Society of America

|June 6, 2023

概括

双频组织可以成功地分离肌病肌,与健康肌不同. 这种方法在治疗肌损伤方面表现有前途,通过克服对组织缩分离的抵抗力.

科学领域:

医学物理医学物理
生物医学工程生物医学工程
组织工程是组织工程.

背景情况:

组织缩有效地分裂软组织,但与健康的肌作斗争.
正在探索预热和多频方法,以提高肌对组织缩的敏感性.

研究的目的:

评估单频和双频基因组的疗效,以分离健康和肌病的牛肌.
研究不同频率及其组合在肌分离中的作用.

主要方法:

活体牛肌 (4个健康,8个肌病) 用单 (1.07,1.5,3.68MHz) 和双频 (1.07/1.5MHz,1.5/3.68MHz) 组织缩治疗.
用高速摄影在幻影中研究了泡动力学.
使用被动化探测器 (PCD) 监测化活动.
经过治疗的肌被粗略和组织学评估.

主要成果:

双频 (1.5 和 3.68 MHz) 组织缩导致肌病肌产生分离孔.
单频 (1.5 或 3.68 MHz) 暴露导致肌病肌的焦点干扰.
在所有测试频率上,健康的肌只显示热性亡.
单独或组合的1.07MHz暴露,没有达到肌病肌的分离.
PCD检测到洞穴的差异,但无法可靠地预测分成的成功.

结论:

双频组织,特别是使用1.5和3.68MHz,显示出肌病肌完全分化的潜力.
在测试条件下,健康的肌仍然可以抵抗组织缩分离.
组织缩参数,特别是频率组合,对于实现向组织分离至关重要.

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