细菌病原体的COVID-19前后抗微生物耐药性概况,在三级医院进行的一项比较研究
Mohammed H Taleb1, Abdelraouf A Elmanama2, Alaa H Taleb3
1Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Al-Azhar University-Gaza, Gaza, Palestine.
Journal of infection in developing countries
|June 6, 2023
概括
抗菌素耐药性 (AMR) 在COVID-19后增加了一些药物,特别是那些没有处方使用的药物. 建议对医院进行管理和限制药店销售,以打击AMR的上升.
科学领域:
- 微生物学与传染病的研究
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 抗微生物耐药性 (AMR) 是一种天然的细菌进化,因抗微生物药物滥用而加剧.
- 由于抗微生物药物使用的改变,COVID-19大流行可能影响了AMR模式.
- 了解AMR趋势对于有效的感染控制和治疗策略至关重要.
研究的目的:
- 调查关键细菌病原体抗微生物耐药性 (AMR) 模式的变化.
- 为了比较COVID-19前后期间在加沙地带的一家三级护理医院的AMR趋势.
- 为了识别表现出显著耐药性变化的特定抗菌剂.
主要方法:
- 追溯观察性研究分析了从2039个COVID-19前样本和1827个COVID-19后样本的细菌培养数据.
- 从加沙地带一家三级医院的微生物学实验室记录中收集的数据.
- 使用SPSS软件进行Chi-square测试进行统计比较.
主要成果:
- 在这两个时期,大肠杆菌是最常见的病原体;整体AMR率仍然很高.
- 在COVID-19后观察到克洛克萨西林,红素,塞法列辛,co-trimoxazole和阿莫西西林/克拉夫兰酸的耐药性显著增加.
- 在COVID-19后,对素,素, gentamicin,doxycycline, rifampicin, vancomycin 和 meropenem 的耐药性显著下降.
结论:
- 在大流行期间,抗菌素对受限制和非社区抗菌素的抗菌素耐药性下降.
- 抗微生物药物的耐药性增加,这些抗微生物药物经常在没有医疗处方的情况下使用.
- 建议包括限制非处方药的抗微生物销售,实施医院抗微生物管理,提高公众意识.
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