基于美素的组合疗法成功治疗了两个超寄生虫性Plasmodium falciparum病例
Benudhar Mukhi1, Himanshu Gupta2, Kishore Punnath3
1Indian Council of Medical Research (ICMR)-National Institute of Malaria Research, New Delhi, India.
Journal of infection in developing countries
|June 6, 2023
概括
两名超寄生性疟疾患者通过基于美素的联合治疗 (ACT) 完全康复. 这项案例研究突出显示了Plasmodium falciparum疟疾的成功治疗结果,即使寄生虫负载很高.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 寄生虫学的寄生虫学
背景情况:
- 超寄生病是Plasmodium falciparum严重疟疾 (SM) 的关键因素,可能导致致命的并发症.
- 早期检测和治疗对于管理严重疟疾和预防不良结果至关重要.
研究的目的:
- 报告两例Plasmodium falciparum疟疾超寄生病的病例,没有危及生命的并发症.
- 评估基于美素的组合疗法 (ACT) 在治疗超寄生性血症方面的疗效.
主要方法:
- 使用血液涂抹和快速诊断测试 (RDTs) 诊断疟疾.
- 根据世界卫生组织 (WHO) 的指导方针计算寄生虫血症.
- 血液学,生化学和每周的随访调查持续63天.
主要成果:
- 两名患有高寄生素血症的患者 (42%和9.5%) 通过ACT和一次剂量primaquine成功恢复.
- 在63天的随访期间,没有检测到寄生虫,这表明治疗成功,没有副作用.
- 一名患者呈现出很大比例的性阶段寄生虫 (超细胞血症).
结论:
- 基于美素的组合疗法 (ACT) 在治疗Plasmodium falciparum超寄生病症方面是有效的,即使是在没有立即并发症的严重病例中也是如此.
- 存在高血球细胞血症需要立即治疗,以防止可能阻碍疟疾消除工作.
关键词:
ACT ACT ACT 是一个字母.原菌 (Plasmodium falciparum) 是一种有毒的病毒.过多的游戏细胞血症.过度寄生性血症是什么意思普莱马奎因 (primaquine) 是一种主要的类动物.严重的疟疾严重的疟疾.更多相关视频
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