抗生素耐药性评估和从临床样本中分离的Enterococcus faecium的多种药物排泄
Mehdi Mirzaii1, Masoud Alebouyeh2, Mohammad Bagher Sohrabi3
1Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Journal of infection in developing countries
|June 6, 2023
概括
新型排泄抑制剂,如 thioridazine 显示与西普洛素的协同效应,提供了对抗抗诺基诺抗 Enterococcus faecium 感染的新希望.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 肠球菌 (Enterococcus faecium) 是社区和医院感染的重要原因.
- 在E. faecium中,基诺耐药性是一个越来越令人担忧的问题,需要新的治疗策略.
- 排泄在赋予E. faecium. 中诺耐药性的过程中起着至关重要的作用.
研究的目的:
- 为了研究一种排泄抑制剂 (EPI) - - 里达与西普罗夫洛克萨对E. faecium的临床分离物的协同作用.
- 评估向排水的潜力,以克服E. faecium.中的化诺抗性.
主要方法:
- 研究了88种E. faecium的临床分离物.
- 使用表型和分子方法确定抗生素耐药性概况和排泄基因频率.
- 通过微泡稀释测量了含有或不含里达的西普罗素的最小抑制度 (MIC).
主要成果:
- 观察到高耐药率的西普洛素 (96.8%) 和莱沃素 (94.3%).
- 发现的常见排泄基因包括efmA (60-68%),emeA (48-54.5%) 和efrA/efrB (45-51%).
- 提奥里达显示出协同作用,在48.2%的隔离物中,减少了西普洛克萨MIC的至少两倍.
结论:
- 排泄抑制基因在临床E. faecium分离物中普遍存在.
- 蒂奥里达与西普罗夫洛克萨具有协同作用,支持其用于治疗耐诺的E. faecium感染.
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