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相关概念视频

Antigen Processing Pathways01:31

Antigen Processing Pathways

1.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

13.0K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

565
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
565

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相关实验视频

Updated: Jul 27, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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贝叶斯的方法来估计MHC结合值的值.

Ran Liu1, Ye-Fan Hu2,3,4, Jian-Dong Huang2,5,6,7,8

  • 1Department of Statistics, The Chinese University of Hong Kong, Hong Kong SAR, China.

Briefings in bioinformatics
|June 6, 2023
PubMed
概括

这项研究引入了一种新的贝叶斯模型,自动确定主要基因相容性复合体 (MHC) -结合值. 这种数据驱动的方法提高了免疫疗法应用的准确性.

关键词:
有约束力的门.结合MHC-的结合方式动机采样采样 动机采样

更多相关视频

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
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Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells

Published on: October 22, 2012

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相关实验视频

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07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

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Peptide:MHC Tetramer-based Enrichment of Epitope-specific T cells
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科学领域:

  • 免疫学 免疫学 免疫学
  • 计算生物学 计算生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 主性基因相容性复合体 (MHC) - 结合对于T细胞识别和免疫治疗至关重要.
  • 现有的方法可以预测结合亲和力,但很难推断出准确的结合值,通常使用任意值.
  • 不同的MHC分子可能具有不同的结合值,需要采用数据驱动的方法.

研究的目的:

  • 开发一种自动化,数据驱动的方法来确定MHC-结合值.
  • 同时推断结合点,结合亲和力和结合值.
  • 为每个MHC提供一个后部分布的约束值.

主要方法:

  • 提出了贝叶斯模型,用于联合推断核心位置,绑定亲和力和绑定值.
  • 进行了模拟研究,使用不同的动图分布和随机序列比例.
  • 将模型应用于现实世界的MHC结合数据.

主要成果:

  • 贝叶斯模型准确地估计了约束值,为每个MHC提供后向分布.
  • 模拟研究证明了模型在不同场景中的准确性和稳定性.
  • 该模型在应用于真实数据时,表现优于常用的任意值.

结论:

  • 开发的贝叶斯模型提供了一个准确和数据驱动的方法来确定MHC-结合值.
  • 这种方法增强了对T细胞抗原呈现在免疫治疗中的预测.
  • 这些发现表明,分析MHC-相互作用的方法比传统的临时标准更精确.