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用于PROTAC蛋白质降解剂的口服吸收的物理化学性质决定因素

Keith R Hornberger1, Erika M V Araujo1

  • 1Arvinas Operations, Inc., 5 Science Park, 395 Winchester Avenue, New Haven, Connecticut 06511 United States.

Journal of medicinal chemistry
|June 6, 2023
PubMed
概括

蛋白质溶解向化马体 (PROTACs) 的口服吸收是新疗法的关键. 这项研究确定了影响PROTAC在老鼠口服吸收的物理化学特性,有助于开发口服药物.

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