在手术后的长期复发率在初级甲状腺功能障碍症的手术后
Muizz Zaman1, Laxshika Raveendran1, Ayla Senay2
1Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
The Journal of clinical endocrinology and metabolism
|June 6, 2023
概括
初级甲状腺功能障碍症 (PHPT) 的副甲状腺切除术后的复发率很低,为0.23%和1.03%的5年和10年率. 建议在手术后对PHPT患者进行长期随访.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 临床研究 临床研究
背景情况:
- 原发性副甲状腺症 (PHPT) 是高血症的最常见原因.
- 在PHPT治疗手术后的长期复发率尚不清楚.
研究的目的:
- 进行第一个系统性审查和对甲状腺切除术后零星PHPT长期复发率的元分析.
- 为了调查手术干预后5年和10年的复发率.
主要方法:
- 进行全面的数据库搜索 (PubMed,EMBASE,Cochrane等) 在2023年1月之前.
- 包括至少有5年的随访数据的观察性研究.
- 数据提取和使用NIH工具进行质量评估,由两个独立审查员进行.
主要成果:
- 在30,658名参与者中,整体复发率为1.56% (95% CI 0.96-2.28%).
- 5年复发率为0.23% (0.04-0.53%) 和10年复发率为1.03% (0.45-1.80%). 综合的5年复发率为0.23% (0.04-0.53%) 和10年复发率为1.03% (0.45-1.80%).
- 根据初始诊断或手术方法,复发率没有显著差异.
结论:
- 大约1.56%的零星PHPT患者经历了副甲状腺切除术后的复发.
- 复发率不受初始诊断或手术类型的影响.
- 持续的长期患者随访对于识别复发性疾病至关重要.
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