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甲状腺功能测试在儿童和青少年与三胞体21:定义的综合征特定的参考范围范围
Alessandro Cattoni1,2, Silvia Molinari1, Giulia Capitoli3
1Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza (MB), Italy.
The Journal of clinical endocrinology and metabolism
|June 6, 2023
概括
儿科唐氏综合征 (DS) 患者具有独特的甲状腺功能测试 (TFT) 范围. 新的诺基图显示TSH较高,FT3/FT4较低,有助于在DS儿童中准确诊断甲状腺功能低下症.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 遗传学 遗传学 是一个
- 甲状腺学 甲状腺学
背景情况:
- 唐氏综合征 (DS) 与甲状腺功能障碍有关.
- 目前的甲状腺功能测试 (TFT) 参考范围可能会高估儿科DS患者的甲状腺功能低下症,因为缺乏综合征特异性数据.
研究的目的:
- 为患有唐氏综合征的儿科患者建立年龄相关的TFT参考范围 (名图).
- 在这个人群中描述TFT随时间变化的变化.
- 评估提升甲状腺激素 (TSH) 对未来甲状腺功能低下的预测值.
主要方法:
- 从1992年到2022年,对548名儿科DS患者 (0-18岁) 进行了回顾性观察研究.
- 排除患有甲状腺解剖异常,影响甲状腺的治疗或阳性甲状腺自身抗体的患者.
- 对TSH,FT3和FT4水平的纵向评估,以创建特定年龄的名录.
主要成果:
- 已建立的TSH,FT3和FT4的综合征特异性名录在儿科DS.
- 与非DS对照组相比,所有年龄段的TSH水平中位数显著更高.
- 在特定年龄组中,FT3和FT4水平的中位数较低.
- 随着时间的推移,TSH水平表现出显著的个体内波动.
- TSH的第75百分位预测了未来的甲状腺功能低下症,具有良好的负值但较差的积极预测值.
结论:
- 在儿科DS患者的长度TFT评估产生了综合征特异性参考名图.
- 与对照组相比,在DS患者中观察到TSH水平的持续上升.
- 这些名图对于准确诊断和治疗小儿唐氏综合征的甲状腺功能障碍至关重要.
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