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在重建性外科手术中移植组织的采购和开发:叙述性综述

Sabrina Shih¹, Carly Askinas¹, Sarah Caughey¹

¹Division of Plastic and Reconstructive Surgery, Department of Surgery, Weill Cornell Medical Center/New York-Presbyterian Hospital, New York, NY, United States of America.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

|June 6, 2023

概括

整形和重建外科医生使用异构和异构组织产品,采购和监管各种应用. 基因编辑的进步正在扩大异种移植器官移植的潜力.

科学领域:

生物医学工程生物医学工程
手术创新在外科创新.
组织工程是组织工程.

背景情况:

同源性和异源性组织在重建性手术中为自身移植提供了替代方案,减少了捐赠者部位的发病率.
人类细胞,组织和基于细胞和组织的产品 (HCT/Ps) 受到FDA的监管,由美国组织银行协会 (AATB) 自愿认证.
异种组织,主要来自猪或牛的来源,经过严格的查传染病.

研究的目的:

提供关于异种和异种组织产品的采购,监管,加工和应用的概述.
突出塑性和重建性外科手术中基于组织的解决方案的不断变化的景观.
讨论最近的进展,包括用于异种移植的基因编辑.

主要方法:

审查目前组织银行和监管框架的现行做法.
对所有移植和异种产品的加工技术的分析.
检查在重建性手术和研究中的历史和新兴应用.

主要成果:

异构组织被加工成移植用于重建或用于研究和培训.
外源性产品,通常是脱细胞化,可用于外科手术.
基因编辑技术正在为异种器官移植铺平道路.

结论:

异构和异构组织是塑性和重建性外科手术中的重要资源.
严格的监管监督确保了组织产品的安全性和有效性.
目前正在进行的研究和技术进步继续扩大基于组织的疗法的实用性.

关键词:

美国食品和药物管理局 (FDA) 的规定.消毒灭菌消毒灭菌消毒灭菌组织银行是组织银行.组织采购组织采购异种移植异种移植

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