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相关概念视频

Bacterial Transcription01:53

Bacterial Transcription

28.7K
RNA polymerase (RNAP) carries out DNA-dependent RNA synthesis in both bacteria and eukaryotes. Bacteria do not have a membrane-bound nucleus. So, transcription and translation occur simultaneously, on the same DNA template.
Transcription can be divided into three main stages, each involving distinct DNA sequences to guide the polymerase. These are:
28.7K
Transcription Elongation Factors02:35

Transcription Elongation Factors

11.0K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
11.0K
Transcription01:10

Transcription

147.3K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
147.3K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

7.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
7.4K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

2.0K
2.0K
Eukaryotic Transcription Activators02:42

Eukaryotic Transcription Activators

11.1K
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These...
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相关实验视频

Updated: Jul 27, 2025

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

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吸收转录凝聚物的洗.

Min Kyung Shinn1, Rohit V Pappu1

  • 1Department of Biomedical Engineering and Center for Biomolecular Condensates, James F. McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

Developmental cell
|June 6, 2023
PubMed
概括

转录因子形成凝结物,但它们在转录中的功能尚不清楚. 新的研究表明,DNA和调节剂充当表面活性剂,影响凝结物的活性.

科学领域:

  • 分子生物学分子生物学
  • 细胞生物学 细胞生物学
  • 生物化学 生物化学

背景情况:

  • 转录因子 (TF) 可以形成类似液体的凝结物.
  • 这些凝聚物在调节基因转录中的确切作用尚未完全理解.

研究的目的:

  • 研究转录因子凝结物影响转录活性的机制.

主要方法:

  • 这项由王等人进行的研究. 研究了DNA和转录调节器与TF凝聚物的相互作用.

主要成果:

  • 发现向DNA和转录调节器可以吸附到TF凝聚物上.
  • 这些分子作为表面活性剂,类似于肥,改变凝结物质的特性.

结论:

  • DNA和调节物的吸附在凝聚物上调节了转录凝聚物的活性.
  • 这为转录如何在分子水平上受到调节提供了新的机械洞察力.

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