相关实验视频
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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预测CKD进展和心血管事件使用白膜病和脉冲波速度
Rasmus Kirkeskov Carlsen1,2, Dinah Sherzad Khatir1, Danny Jensen1
1Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Kidney & blood pressure research
|June 6, 2023
概括
尿中的白蛋白-肌氨酸比率预测慢性病 (CKD) 的进展和不良心血管事件. 通过脉冲波速度 (PWV) 测量的动脉硬度在这个CKD患者队列中没有显示出预测值.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 生物标志物发现发现
背景情况:
- 慢性病 (CKD) 显著增加心血管疾病 (CVD) 和死亡率的风险.
- 已经确立的生物标志物,如白蛋白尿是至关重要的,但需要额外的预测对CKD进展和心血管疾病.
- 动脉硬度,通过带-大腿脉冲波速率 (PWV) 进行评估,是与心血管疾病和死亡率相关的可测量参数.
研究的目的:
- 评估尿白蛋白-肌素 (UAC) 比率和PWV对CKD进展,心血管事件和死亡率的预测能力.
- 确定可靠的生物标志物,用于在3-5阶段的CKD患者中进行风险分层.
主要方法:
- 181名CKD 3-5期患者的队列具有UAC和PWV的基线测量.
- 慢性病的进展是由50%的EGFR下降,透析开始或移植定义的.
- 综合终点包括CKD进展,心肌梗塞,中风或死亡,使用调整后的Cox回归来分析.
主要成果:
- 在调整后的分析中,尿中的白蛋白-肌素比率 (UAC) 显著预测了CKD进展 (HR 1.5) 和复合终点 (HR 1.4).
- 带-大腿脉冲波速率 (PWV) 与CKD进展 (HR 0.99) 或复合终点 (HR 1.03) 没有关联.
- 这项研究包括了181名患者,平均随访时间为4年,观察了44例CKD进展和89例复合事件.
结论:
- 尿中的白蛋白-肌氨酸比率作为一个有价值的预测者,对CKD进展和不良结果在老龄化的CKD人口.
- 脉冲波速度 (PWV) 在这个队列中没有证明对CKD进展或复合终点的预测效用.
- 这些发现强调了UAC作为预后生物标志物在治疗慢性病患者中的重要性.
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