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尼维与外围球体的自然进化
Paula Anca Ilut1, Elisa Camela2, Konstantinos Lallas3
1Department of Dermatology, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Dermatology (Basel, Switzerland)
|June 6, 2023
概括
骨中的外周血球 (PG) 的平均增长率为0.16mm2/月,不依赖患者的年龄,性别或位置. 具有均皮肤镜图案的Nevi显示出最高的生长率,没有病变进展为黑色素瘤.
科学领域:
- 皮肤病学 皮肤病学
- 皮肤镜检查 (dermoscopy) 是一种可以检查皮肤的方法.
- 黑色细胞病变的病变
背景情况:
- 周围球体 (PG) 是黑色细胞病变中的皮肤学特征,可能表明瘤和黑色素瘤的生长.
- 需要进一步阐明PG的自然演变及其基于年龄的管理.
研究的目的:
- 为了确定带有外围球体 (PG) 的黑色细胞病变的生长速度.
- 调查PG生长与患者年龄,性别,病变位置和皮肤镜图案之间的关联.
主要方法:
- 对接受顺序数字皮肤镜监测的白人患者的回顾性分析.
- 包括PG的病变覆盖≥75%的周长,随着后续图像或组织病理学.
- 独立研究人员自动计算表面积和评估皮肤学标准.
- 应用生长曲线模型来评估病变区域随时间变化.
主要成果:
- 总共分析了98名患者的208个病变,平均随访时间为18个月.
- 患有PG的神经瘤的平均生长率为0.16 mm2/月 (p < 0.001).
- 在具有均皮肤镜图案 (p < 0.001) 的斑块中观察到更高的生长率.
- 随访期间,外围球粒数量各不相同,并且没有任何病变显示出黑色素瘤特异性结构.
结论:
- 带有外围球体的Nevi平均生长率为0.16 mm2/月,不受年龄,性别或位置的影响.
- 同质的皮肤镜图案与这个队列中最高的生长率有关.
- 在研究期间,没有监测的PG瘤在研究期间发展出有关黑色素瘤特异性标准.
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