与一般人群相比,肌肉炎患者的心血管风险较大
Sabina Oreska1,2, Hana Storkanova1,2, Aneta Pekacova1,2
1Institute of Rheumatology, Prague, Czech Republic.
Rheumatology (Oxford, England)
|June 6, 2023
概括
与健康对照组相比,患有异常性炎症性肌肉病 (IIM) 的患者心血管风险和亚临床动脉样硬化风险较高. 传统的风险评分对于预测IIM患者的CV风险是不准确的.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 血管医学 血管医学
背景情况:
- 异常性炎症性肌肉病变 (IIM) 与心血管 (CV) 发病率和死亡率的增加有关.
- 了解IIM患者的心血管风险概况对于早期检测和预防至关重要.
研究的目的:
- 与健康对照组 (HC) 相比,评估IIM患者的心血管风险.
- 评估心血管风险与IIM的疾病特征之间的关联.
- 在IIM中确定传统心血管风险得分的准确性.
主要方法:
- 纳入了90名IIM患者和180名年龄/性别匹配的HC患者,不包括那些先前患有心血管疾病的患者.
- 血管评估包括动脉内心介质厚度 (CIMT),脉冲波速度 (PWV) 和脚-手臂指数 (ABI).
- 用系统慢性风险评估 (SCORE) 和修改版来评估心血管风险.
主要成果:
- 与HC相比,IIM患者表现出传统心血管风险因素,动脉疾病 (CARD) 和异常的ABI/PWV的更高患病率.
- 即使在对传统风险因素进行匹配后,在IIM患者中,CARD和异常PWV仍然显著高.
- 传统的风险评分 (例如,SCORE) 对于预测IIM心血管风险是不准确的,年龄,疾病活动和其他因素是重要的预测因素.
结论:
- IIM患者面临的传统心血管风险因素和亚临床动脉样硬化症的负担显著增加.
- 目前的CV风险预测模型可能低估了IIM中的风险,需要定制的评估策略.
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