下肢深静脉血栓的导导管血栓溶解协议 - 一个系统的审查和元分析
Luís Duarte-Gamas1,2, Filipa Jácome1,2, Lara Romana Dias1,2
1Department of Angiology and Vascular Surgery, São João University Hospital Center, Porto, Portugal.
Thrombosis and haemostasis
|June 6, 2023
概括
导管血栓溶解 (CDT) 是一种低风险的治疗方法,用于治疗下肢深静脉血栓 (LE-DVT). 然而,由于治疗方案的多样性,很难评估后血栓塞综合征等结果.
科学领域:
- 血管外科 血管外科
- 干预性放射学 干预性放射学
- 心脏病学 心脏病学
背景情况:
- 下肢深静脉血栓塞 (LE-DVT) 是一种严重的血管疾病.
- 导管血栓溶解 (CDT) 是LE-DVT的新兴治疗选择.
- 了解各种CDT协议的有效性和安全性至关重要.
研究的目的:
- 系统地审查和总结不同的导管血栓溶解 (CDT) 协议的特征,并发症和成功率,以治疗下肢深静脉血栓症 (LE-DVT).
主要方法:
- 进行了随机对照试验和观察性研究的系统审查和元分析.
- 在电子数据库 (MEDLINE,Scopus,Web of Science) 中搜索相关的LE-DVT和CDT研究.
- 早期并发症,血栓后综合征 (PTS) 和静脉通透率的聚合比例是使用随机效应模型计算的.
主要成果:
- 分析了46项研究,包括49个方案和3028名参与者.
- 在90%的LE-DVT病例中存在阴茎关节干扰.
- 综合的并发症率包括轻微出血 (8.7%),严重出血 (1.2%),肺栓塞 (1.1%) 和死亡 (0.6%).
- 一年后的PTS和静脉通透率的综合发病率分别为17.6%和77.5%.
结论:
- 导导管血栓溶解 (CDT) 证明了治疗LE-DVT的低风险概况.
- CDT协议的异质性使得评估结果变得更加复杂,特别是血栓后综合征 (PTS) 发生率.
- 进一步标准化CDT协议可能会提高结果的可预测性.
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