与炎症反应相关的基因预测HNSCC患者的预后
Si-Li Jing1, Keihan Afshari2, Zhi-Chen Guo3
1Shannxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an, 710004, China.
Immunology letters
|June 6, 2023
概括
一个新的基因签名识别了9个与炎症反应相关的基因,这些基因预测了头部和部状细胞癌 (HNSCC) 的预后. 这种签名反映了免疫状态,并可能为HNSCC患者提供治疗点.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 头角状细胞癌 (HNSCC) 是一种常见的癌症,瘤微环境,特别是炎症,影响患者的结果.
- 在HNSCC进展中炎症的确切作用仍然不完全理解.
研究的目的:
- 为了确定关键的炎症反应相关基因与HNSCC的预后相关.
- 根据炎症标志物开发HNSCC患者预测结果的基因特征.
- 探索这种基因特征,免疫状况和潜在的治疗点之间的关系.
主要方法:
- 利用癌症基因组图谱 (TCGA) 数据库用于HNSCCmRNA表达和临床数据.
- 雇佣的最小绝对缩小和选择操作员 (LASSO) 考克斯回归以确定预后基因.
- 进行了卡普兰-梅尔分析,ROC曲线分析和单变量/多变量考克斯分析以预测存活率.
- 使用单样样本基因组丰富分析 (ssGSEA) 评估免疫细胞透和通路活性.
- 使用基因表达造型交互分析 (GEPIA) 和免疫组织化学验证了基因和蛋白质表达.
主要成果:
- 建立了一个与9基因炎症反应相关的特征,显著区分高风险和低风险HNSCC患者.
- 高风险组的整体存活率 (OS) 显著降低.
- 从签名中获得的风险得分作为OS的独立预测指标,与瘤阶段和免疫亚型相关.
- 基因表达水平与对抗瘤药物的敏感性相关,高表达预测预后不佳.
结论:
- 一个新的9基因特征准确地反映了HNSCC中的免疫微环境,并预测了患者的预后.
- 这种签名具有作为预后工具的潜力,并可能为HNSCC治疗确定新的治疗点.
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