可降解的水凝用于持续局部输送抗瘤药物
Torben Lessmann1, Seth A Jones1, Tobias Voigt1
1Ascendis Pharma GmbH; Im Neuenheimer Feld 584, 69120 Heidelberg, Germany.
Journal of pharmaceutical sciences
|June 6, 2023
概括
一种新的水凝前药物技术 (TransCon Hydrogel) 能够持续,局部地提供抗癌药物,提高疗效,降低全身毒性,改善癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 系统性免疫调节性抗瘤疗法具有低效率和高毒性.
- 内注射药物导致药物迅速流出,减少局部暴露和治疗效益.
- 暂时合 (TransConTM) 技术为持续的药物输送提供了一种经过验证的方法.
研究的目的:
- 开发和描述水凝微球,用于局部,持续释放的抗癌剂.
- 评估TransCon水凝系统的药物释放特征和降解特征.
- 评估这项技术在改善癌症疗法的治疗指数方面的潜力.
主要方法:
- 使用基于PEG的聚胺树脂和交叉连接剂设计和合成水凝微球.
- 抗癌药物 (resiquimod和axitinib) 通过可切割的链接剂进行共价附着.
- 在体外鉴定药物释放动力学和在生理条件下的水凝降解.
主要成果:
- 水凝微球成功封装,并在几周内提供了持续释放的resiquimod和axitinib.
- 在水凝载体显著物理降解之前观察到药物释放.
- 该TransCon水凝系统显示了高局部药物度的潜力,使系统暴露最小化.
结论:
- 跨孔水凝技术为癌症治疗提供局部,持续的药物输送.
- 这种方法可以增加局部药物暴露,同时减少系统性不良事件.
- 目前正在进行临床试验,以研究用于固体瘤的resiquimod水凝前药物.
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