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按摩对视网醇透皮肤的影响

Tiffanie Salas¹, Claire Bordes², Delphine Arquier²

¹Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5007, Laboratoire D'Automatique, de Génie des Procédés et de Génie Pharmaceutique (LAGEPP), 43 Bd Du 11 Novembre 1918, 69622 Villeurbanne, France; Groupe SEB, Campus SEB, 112, Chemin Du Moulin Carron, Ecully, France.

International journal of pharmaceutics

|June 6, 2023

概括

按摩技术显著影响着护肤成分 (如视网醇) 如何透到皮肤. 滚动式按摩比旋转式按摩更有效地提高了网膜醇在表皮和皮肤中的吸收.

科学领域:

皮肤病学和化品科学
药理动力学和药物输送方法

背景情况:

优化局部活性物质的输送涉及载体配方和应用协议.
虽然配方方面有充分的研究,但应用方法,如按摩,在护肤方面研究较少.
雷丁醇是一种脂性抗衰老剂,通常用于化品配方.

研究的目的:

为了研究不同按摩应用协议对皮肤透的雷丁醇的影响.
为了评估按摩类型 (滚动与旋转) 和时间对视网醇吸收的影响.
评估按摩作为局部化品交付增强的潜力.

主要方法:

在弗朗茨扩散细胞中,应用在猪皮上使用的猪皮扩散剂上,含有雷丁醇的配方.
按摩 (滚筒或旋转类型) 在配方沉积后或之前应用.
多样化按摩时间和类型,以评估对皮肤透的影响.

主要成果:

按摩方案显著影响了视网醇的皮肤透.
由于其脂友性质,视网醇在角层中积累.
与旋转按摩相比,卷式按摩在4小时后显著增加了表皮和皮肤中的视网醇度.

结论:

应用方案,特别是按摩的类型,在局部视网醇输送中起着至关重要的作用.
滚动式按摩是一种比旋转式按摩更有效的方法,可以提高视网醇的皮肤透率.
这些发现支持开发按摩设备,以提高化品配方的疗效.

关键词:

实验设计实验设计按摩效果的按摩效应网红醇是什么网红醇皮肤老化皮肤老化穿透皮肤的方法

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