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相关概念视频

Flow Table Test01:12

Flow Table Test

204
The flow table test is an established method used to assess the workability of concrete, particularly useful for evaluating highly flowable concrete mixes. This test employs an apparatus that consists of a wooden board topped with a steel plate, collectively weighing 35 pounds. The board is connected to a base via a hinge and measures 27.6 inches on each side.
Concrete is placed within a truncated cone mold that is 8 inches high with an 8-inch base diameter and a 5-inch top diameter. The...
204
Pipe Flowrate Measurement: Problem Solving01:28

Pipe Flowrate Measurement: Problem Solving

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A spray tank system is engineered to uniformly distribute a pest-control liquid across plants by using a pressurized mechanism. The tank, pressurized to 150 kPa, holds the pesticide at a height of 0.80 meters. Liquid flows from the tank through a 1.9 meter pipe with a diameter of 0.015 meters, angled at 0.698 radians, ultimately reaching a 0.007 meter nozzle that sprays the pesticide. Accurate calculation of the system's flow rate is crucial to ensure uniform application, and this is...
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相关实验视频

Updated: Jul 27, 2025

Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders
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综合性粉末流量表征与减少的测试.

Catarina Chendo1, João F Pinto2, Maria C Paisana1

  • 1R&D Analytical Development, Hovione Farmaciência S.A., 1649-038 Lisboa, Portugal.

International journal of pharmaceutics
|June 6, 2023
PubMed
概括
此摘要是机器生成的。

这项研究使用rheological技术来描述药物粉末混合物,以了解粉末流动. 收益率位测试被推用于全面的流动性评估,减少早期开发测试.

关键词:
流动性 流动性 流动性口服用药的剂量表格可以使用.粉末混合物 粉末混合物类风病学 类风病学 类风病学环剪切细胞测试试验

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 粉末流动对于制药混合物统一性和药片生产至关重要.
  • 描述粉末属性和组件间相互作用是理解混合物行为的关键.

研究的目的:

  • 用各种类风湿学技术来对药物粉末混合物进行表征.
  • 为了确定哪些类风学试验提供了最有信息的混合物流动性数据.
  • 减少早期制药开发阶段所需的测试数量.

主要方法:

  • 对两个凝聚性粉末的评估:喷雾干燥的基纤维素 (SD HPMC) 和微缩的印美他辛 (IND).
  • 用常见辅助剂配制混合物:乳糖单 (LAC),微晶纤维素 (MCC),酸 (MgSt) 和合体二氧化 (CS).
  • 应用多种类型的风湿学技术来评估粉末的流动特性.

主要成果:

  • 粉末的流动性受粒子大小,散密度,形态和滑剂相互作用的影响.
  • 静止角 (AoR),压缩能力百分比 (CPS) 和流量函数系数 (ffc) 都对混合物颗粒大小敏感.
  • 具体能量 (SE) 和内部摩擦的有效角度 (φe) 与粒子形态和滑剂相互作用相关.

结论:

  • 产量位测试提供了关于粉末流动特征的全面数据,包括与形态和滑剂相互作用相关的数据.
  • 利用产量位点测试可以简化粉末流量表征,在早期开发中节省时间和材料.
  • 选择适当的风湿学试验对于高效和有效的药物配方开发至关重要.