尿液电解质并不能预测缺氧皮质皮酸盐在患有低 adrenocorticism 的狗中的有效性
American journal of veterinary research
|June 6, 2023
概括
尿液电解质测试,包括与肌素的比率,对于监测患有低皮质皮质症 (HA) 的狗的矿物质皮质类药物治疗是不可靠的. 这些评估并不准确地反映了在接受脱氧皮质酸盐 (DOCP) 的狗中治疗的充分性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 低 adrenocorticism (HA),或阿迪森氏病,是复杂的内分泌疾病在狗需要终身矿物质皮质和葡萄糖皮质替代疗法.
- 监测治疗的充分性至关重要,以防止治疗不足或治疗过度,这可能导致严重的健康并发症.
- 目前的监测通常依赖于临床症状和血清电解质水平,但寻求更客观的措施.
研究的目的:
- 评估尿液电解质评估对监测具有低上皮质症 (HA) 的狗中矿物质皮质类药物治疗充足性的有用性.
- 为了确定尿液中的,和它们的比率是否与用脱氧皮质酸盐 (DOCP) 治疗的狗的血清电解质和血胆活性相关.
主要方法:
- 纳入了29只自然发生HA的狗的队列.
- 尿液和血清中的,和肌氨酸度被连续测量长达3个月,治疗后用脱氧皮质酸盐 (DOCP).
- 尿液电解质比率 (Na:K,Na:Cr,K:Cr) 分析了与血清值的关联,并根据血仁素活性对治疗不足和治疗过度的组进行了比较.
主要成果:
- 尿中的与肌素 (K:Cr) 比率与DOCP注射后10-14天和30天的血清水平有显著的关联,但确定系数较低 (R2=0.35和0.17).
- 过度治疗的狗在10-14天后的尿液K:Cr比率高于治疗不足的狗 (P=0.039),但在30天后这种差异并不显著.
- 没有其他尿液电解质变量表明治疗不足和过度治疗的狗之间存在显著差异.
结论:
- 尿液电解质测量,包括K:Cr比率,对于评估低皮质皮质症狗中矿物质皮质物 (DOCP) 治疗的充分性是不够可靠的.
- 可能需要进一步的研究来确定更准确,更容易使用的HA管理监测工具.
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