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婴儿格兰氏阴性侵入性细菌感染的发病率在英格兰,2011-2019:使用全人口监测数据的观察性研究
Luisa K Hallmaier-Wacker1, Amelia Andrews2, Russell Hope1
1Healthcare-Associated Infection, Fungal, Antimicrobial Resistance, Antimicrobial Usage & Sepsis Division, UK Health Security Agency, London, UK.
Archives of disease in childhood
|June 6, 2023
概括
在2011-2019年期间,英格兰婴儿的侵入性细菌感染显著增加,主要是由于晚发病例. 这一趋势凸显了对婴儿健康的日益关注,需要进一步研究预防策略.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 公共卫生监督 公共卫生监督
背景情况:
- 侵入性细菌感染 (IBIs) 是全球婴儿死亡的主要原因.
- 格拉姆阴性病原体是婴儿发病率和死亡率的重要贡献者.
研究的目的:
- 估计英格兰婴儿中与格拉姆阴性病原体相关的IBI的发病率和趋势.
- 分析早期发病和晚期发病的感染和多微生物感染的变化.
主要方法:
- 利用英国卫生安全局国家实验室对婴儿 (<1岁) 的监测数据,从2011年4月至2019年3月.
- 确定的早期发病 (<7天) 和晚发病 (≥7天) 感染,以及多微生物感染 (≥2种).
- 用Poisson和β回归来分析发病率和比例的趋势.
主要成果:
- 每年IBI的发病率增加了35.9% (189.8到258.0每10万活产).
- 晚期发病的感染在新生儿和婴儿中显著增加 (p<0.001).
- 大肠杆菌是主要的病原体,多微生物感染几乎翻了一番.
结论:
- 在英格兰,婴儿的グラム阴性IBI已经增加,主要是由于晚期发病的感染.
- 需要进一步的研究来确定预防的风险因素和驱动因素.
- 多微生物感染的增加需要特别注意.
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