循环氧化原酶抑制剂和癌症:缺少的部分
1Department of Pharmacology, Catholic University School of Medicine, Rome, Italy carlo.patrono@unicatt.it.
概括
低剂量阿司匹林和环氧基酶抑制剂在降低结肠直肠癌风险方面显示出有前途. 研究探讨了它们在预防癌症中的作用,特别是在血小板激活和炎症方面.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 阿司匹林是治疗动脉动血栓症的主要抗血小板疗法.
- 低剂量阿司匹林可以选择性地抑制血小板血栓素的产生,提高疗效并降低毒性.
- 观察性研究和元分析表明,阿司匹林和环氧激酶抑制剂可以降低结直肠和其他消化道癌症的风险.
研究的目的:
- 审查阿司匹林和循环氧化酶抑制剂对化学预防作用的证据.
- 讨论阿司匹林在癌症预防中的作用的机制和临床方面.
主要方法:
- 对阿司匹林和癌症风险的观察研究和元分析的分析.
- 随机心血管试验后期分析的综述.
- 对阿司匹林用于腺瘤复发和林奇综合征的随机对照试验的检查.
主要成果:
- 阿司匹林/环氧基因酶抑制剂与降低结直肠癌风险之间存在一致的关联.
- 证据支持阿司匹林在预防零星结直肠腺瘤复发中的作用.
- 阿司匹林在林奇综合征患者中证明了长期预防结直肠癌.
结论:
- 阿司匹林和循环氧基酶抑制剂对结直肠癌具有化学预防潜力.
- 血小板激活和循环氧化酶-2炎症可能是这些益处的基础.
- 需要进一步的研究,以充分阐明阿司匹林在癌症预防中的机制和临床难题.
相关概念视频
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
02:49Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
02:39Positive Regulator Molecules
5.5K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.5K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K