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Updated: Jul 27, 2025

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Published on: November 11, 2016

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潜在的抗抑郁化合物Org 34167通过一种新的作用方式调节HCN通道

Chaseley E McKenzie1, Andrew Hung1, A Marie Phillips1

  • 1Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia (C.E.M., A.M.P., M.S.S., C.A.R, I.C.F.); School of Science, STEM College, RMIT University, Melbourne, VIC, Australia (A.H.); and School of Biosciences, The University of Melbourne, Parkville, VIC, Australia (A.M.P.).

Molecular pharmacology
|June 6, 2023
PubMed
概括

Org 34167,一种潜在的抗抑郁药,通过改变孔隙和电压感应域来抑制人类的HCN1通道. 这种调节会影响道动力学和功能,揭示其抗抑郁机制.

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