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中部和外围炎症的生物标志物调解了艾滋病毒和抑郁症状之间的关联
Arish Mudra Rakshasa-Loots1,2, Nicholas Bakewell3, David J Sharp4,5
1Edinburgh Neuroscience, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK. Arish.MudraRakshasa@ed.ac.uk.
Translational psychiatry
|June 6, 2023
概括
艾滋病毒感染者面临更高的抑郁风险. 这项研究发现,血液和脑脊液中的炎症标志物部分解释了艾滋病毒和抑郁症状之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 艾滋病毒感染者 (PLWH) 的抑郁率增加.
- 在一般人群中,炎症与抑郁症有关.
- 艾滋病毒感染本质上会引起炎症,这表明潜在的调解作用.
研究的目的:
- 调查外围和中心炎症生物标志物是否调解艾滋病毒和抑郁症状之间的关联.
- 为了确定与这种关系相关的特定炎症标志物.
主要方法:
- 从COBRA队列中对PLWH (n=125) 和对照组 (n=79) 的横截面研究.
- 测量了血,脑脊液 (CSF) 和大脑磁共振光谱 (MRS) 的生物标志物.
- 使用后勤回归来评估炎症生物标志物的调解,>10%或减少表明调解.
主要成果:
- PLWH更有可能出现抑郁症状 (OR=3.27).
- 血生物标志物MIG和TNF-α,以及CSF生物标志物MIP1-α和IL-6,调解了艾滋病毒与抑郁症的关联.
- 神经成像生物标志物并没有实质性地调解这种关联.
结论:
- 特定的外周和中心炎症生物标志物部分解释了PLWH中抑郁症风险的增加.
- 针对这些炎症途径可能为管理PLWH抑郁症提供新的途径.
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