与代谢功能障碍相关的脂肪肝病在感染艾滋病毒的人群中
Maurice Michel1,2, Christian Labenz1,2, Angelo Armandi1,3
1Metabolic Liver Research Program, I. Department of Medicine, University Medical Centre Mainz, Mainz, Germany.
Scientific reports
|June 6, 2023
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 在接受抗逆转录病毒治疗 (ART) 的艾滋病毒感染者 (PLWH) 中很常见. 这种情况类似于非酒精性脂肪性肝病 (NAFLD),表明PLWH患者的肝病风险更高.
科学领域:
- 肝病学和传染病的研究
- 代谢障碍和艾滋病毒医学 代谢障碍和艾滋病毒医学
背景情况:
- 艾滋病毒感染者 (PLWH) 中代谢风险因素和非酒精性脂肪性肝病 (NAFLD) 的高患病率.
- 在抗逆转录病毒治疗 (ART) 的PLWH中,关于代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的有限数据.
研究的目的:
- 确定在ART上的PLWH中MAFLD的流行率和特征.
- 在这个人群中,将MAFLD与NAFLD进行比较.
- 评估MAFLD标准在识别有风险的个体中的有用性.
主要方法:
- 在ART上对282个PLWH进行横截面队列研究.
- 振动控制的短暂弹性图 (VCTE) 用于肝硬化和纤维化评估.
- 使用最近的国际共识声明定义的MAFLD,包括子组.
主要成果:
- 在研究队列中,MAFLD的患病率为26.6% (75/282).
- 与非MAFLD个体相比,患有MAFLD的PLWH年龄较大,肝硬度 (LSM) 更高.
- 大多数MAFLD患者超重或肥胖 (77.3%);MAFLD中最大的LSM与2型糖尿病亚组.
结论:
- 在接受ART的PLWH中,MAFLD的流行率很高,与NAFLD相似.
- 新的MAFLD标准可以应用于PLWH.
- 通过MAFLD及其子组来描述PLWH有助于识别那些有慢性肝病风险的人.
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