在完全脊髓损伤的情况下,发生中央节律和模式生成的罕见现象
Karen Minassian1, Aymeric Bayart1, Peter Lackner2,3
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Nature communications
|June 6, 2023
概括
人类脊髓研究揭示了节奏腿部运动的独特机制. 脊髓损伤患者的外周刺激诱导了运动器类似的模式,与肌肉有所区别.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 脊髓损伤研究 脊髓损伤研究
背景情况:
- 中央模式生成器 (CPG) 对于哺乳动物的运动至关重要,但它们在人类中的存在是有争议的.
- 之前的研究并没有最终确定人类的运动器 CPG.
研究的目的:
- 调查人类腰部CPG的存在和功能.
- 在人体中区分脊髓肌和真正的运动器 CPG 活动.
- 探索完整胸部损伤后人类脊髓的能力.
主要方法:
- 一个患有完全胸脊髓损伤的个体的案例研究.
- 分析自发节奏性脊髓肌.
- 通过外周电刺激 (EES) 诱导的节律运动活动的评估.
- 在两种条件下详细分析肌肉激活模式.
主要成果:
- 脊髓肌涉及肌肉电路,而不是运动器 CPG.
- EES引发了明显的模式,具有曲器-延伸器和左右交替,这是机动机 CPG 的特征.
- 在EES期间自发的运动删除,随后的恢复,表明节奏生成和模式形成是独立的过程.
- 这些发现与动物研究中的观察结果一致.
结论:
- 人的腰椎脊髓具有独特的机制来产生节奏的多肌肉模式.
- 发动机CPG或类似的神经回路存在于人类的脊髓中.
- 脊髓损伤研究可以揭示人类中枢神经系统的基本特性.
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