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通过整合素αvβ3识别24-(S) - 基胆固醇的分子基础

Jeevan B Gc1, Justin Chen1, Swechha M Pokharel2

  • 1Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, 992020, USA.

Scientific reports
|June 6, 2023
PubMed
概括

24-(S) - 胆固醇 (24HC) 与整合素αvβ3结合,激活焦粘附激酶 (FAK) 和NFκB通路. 这种氧胆固醇促进了一种促炎反应,类似于25-胆固醇 (25HC).

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