升高的核PIGL会破坏cMyc/BRD4轴,并通过抑制瘤免疫逃避来改善PD-1阻塞疗法

Hua Yu1, Tiezhu Shi1, Linli Yao2

  • 1Precise Genome Engineering Centre, School of Life Sciences, Guangzhou University, Guangzhou, 510006, China.

概括

酸丁-糖甘生物合成类L (PIGL) 重编程瘤微环境增强了伦瓦替尼和PD-1阻塞治疗肝细胞癌 (HCC). 核PIGL可以改善患者的预后,并指导治疗决策.

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