怀孕不良结果在传统心血管风险预测中的作用
Shivani M Reddy1, Nathaniel Wiecha2, Crystal T Nguyen3
1Division of Translational Health Sciences, RTI International, 307 Waverly Oaks Road, #1023, Waltham, MA, 02452, USA. sreddy@rti.org.
Maternal and child health journal
|June 6, 2023
概括
像妊娠高血压疾病和妊娠糖尿病这样的不良妊娠结果 (APOs) 并没有增加女性心血管疾病 (CVD) 风险. 黑人种族是心血管疾病风险的重要预测因素,突出了心血管健康的差异.
科学领域:
- 心血管疾病研究研究
- 妇女健康 妇女健康
- 生殖健康 生殖健康
背景情况:
- 负面的妊娠结果 (APOs) 影响了三分之一的美国女性,是潜在的心血管疾病 (CVD) 风险因素.
- 传统的心血管疾病风险因素已经确立,但APO的独立贡献需要进一步调查.
研究的目的:
- 确定APO是否比传统的风险因素增加了额外的CVD风险.
- 评估将APO纳入心血管疾病风险预测模型是否能提高准确性.
主要方法:
- 生存模型 (Cox比例危险回归) 分析了2306名有怀孕史的女性 (40-79岁) 的心血管疾病事件风险.
- APO包括任何APO,妊娠高血压疾病 (HDP) 和妊娠糖尿病 (GDM).
- 评估了CVD风险预测模型的歧视,校准和净重新分类,包括APO和没有APO.
主要成果:
- 没有发现任何APO,HDP或GDM与心血管疾病结局的时间之间存在显著的关联.
- 包括APO并没有显著改善CVD风险预测模型的歧视或重新分类.
- 黑人种族成为CVD事件最强的预测因素 (HR 1.59-1.62).
结论:
- 当传统的风险因素得到控制时,APO不会产生额外的心血管疾病风险.
- APO没有提高现有的CVD风险模型的预测准确度.
- 黑人种族是心血管疾病的重要预测因素,强调了健康差异.
相关概念视频
01:30Coronary Artery Disease I: Introduction
33
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
33
01:31Adrenergic Antagonists: ɑ and β-Receptor Blockers
524
Third-generation β-blockers, such as labetalol and carvedilol, represent a significant advancement in managing cardiovascular conditions. Unlike conventional β-blockers, which can induce peripheral vasoconstriction, third-generation drugs block α1 adrenoceptors. This promotes vasodilation through several mechanisms, such as increased nitric oxide production, inhibition of calcium ion entry, opening of potassium ion channels, and antioxidant action. Labetalol, for instance, is...
524
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
150
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
150
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
127
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
127
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
43
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
43
01:27Psychoneuroimmunology: Cardiovascular Disease
57
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
57