S100A8,S100A9和S100A8/A9异构体作为胰腺癌诱导的缓解症的新型缓解因子
Wei-Chih Liao1,2, Chih-Ta Chen3, You-Shu Tsai3
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
BMC cancer
|June 6, 2023
概括
胰腺癌 (PC) 缓解症涉及炎症和肌肉消耗. 鉴定出S100A8,S100A9和S100A8/A9蛋白质是导致PC缓冲症的关键因素,可能有助于诊断.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 癌症缓解症影响80%的胰腺癌 (PC) 患者,其特点是炎症,体重减轻和肌肉消耗.
- 识别PC衍生的促炎因素对于理解缓解症和开发治疗策略至关重要.
研究的目的:
- 为了识别PC中具有缓解毒性潜力的促炎因素.
- 调查这些因素在骨肌肉缩中的作用及其与PC患者硬化症的关联.
主要方法:
- 生物信息分析以确定候选因素.
- 在体外实验中评估候选因子的髓管缩诱导能力.
- 结核病患者和没有结核病患者之间瘤和血清中的因子表达的比较.
- 血清水平的统计分析,体重减轻和缓解症预测.
主要成果:
- S100A8,S100A9和S100A8/A9被确定为诱导骨肌肉缩的因素.
- 在PC患者的瘤中观察到S100A8和S100A9的升高表达.
- 在卡切克性PC患者中发现S100A8,S100A9和S100A8/A9的血清水平显著更高.
- 这些因素的血清水平与体重减轻和独立预测的缓冲症正相关.
结论:
- 由于其缩作用,S100A8,S100A9和S100A8/A9是PC诱导缓冲症的潜在致病因素.
- 这些因素与减肥的相关性及其预测价值表明它们在诊断PC诱导的缓解症时具有实用性.
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