母亲的高脂肪饮食增加了成年后代的呼吸道感官内置和反射支气管收缩
Gina N Calco1, Yem J Alharithi2, Kayla R Williams1
1Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, United States.
概括
在小鼠中,母亲的高脂肪饮食会让后代患上喘. 这种饮食增加了呼吸道感觉神经,导致后代的呼吸道过敏反应,即使在正常饮食中.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 孕产妇肥胖与后代喘风险增加有关.
- 这种关联背后的机制仍然不清楚.
- 现有的模型缺乏人类代谢的相关性.
研究的目的:
- 调查母亲高脂肪饮食对后代气道功能和内置的影响.
- 建立一个模仿肥胖母亲后代人类代谢异常的小鼠模型.
主要方法:
- 开发了一个小鼠模型的孕产妇饮食诱导的肥胖.
- 评估代谢参数 (脂肪,胰岛素抵抗) 和后代的呼吸道反应.
- 利用3D共聚焦成像来分析气道感官内内和物质P的表达.
主要成果:
- 高脂肪饮食 (HFD) 的后代表现出增加的脂肪,高胰岛素血症和胰岛素耐药性.
- 在HFD母的后代中观察到增加的支气管收缩,由气道神经介导.
- 在后代的气道中发现了升高的上皮感官内置和物质P表达.
结论:
- 母亲高脂肪饮食计划后代的气道,增加感官内置,导致反射气道过敏反应.
- 这项研究发现了一种新的机制,将母亲的饮食与后代的喘风险联系起来.
- 研究结果表明,需要针对孕产妇营养的预防策略.
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