结直肠癌中lncRNAs与mTOR的相互作用:一个系统性审查
Marziyeh Sadat Moslehian1,2, Roya Shabkhizan1,2, Mohammad Reza Asadi2
1Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC cancer
|June 6, 2023
概括
长非编码RNAs (lncRNAs) 在结直肠癌 (CRC) 中表现异常,影响mTOR通路. 了解这些lncRNA为新的CRC分子疗法提供了潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题,排名第三最常见的癌症和癌症相关死亡的第四大原因.
- 长非编码RNAs (lncRNAs) 是一种非编码RNAs类,在细胞功能中起着至关重要的作用,并且越来越多地与癌症的发展有关.
- 异常的lncRNA表达是包括CRC在内的各种癌症的标志,表明它们参与瘤发生.
研究的目的:
- 系统地审查和评估异常的mTOR相关 lncRNAs 在结直肠癌瘤发生中的作用.
- 在CRC的背景下,识别与mTOR信号通路相互作用的特定lncRNA.
- 探索针对这些 lncRNAs 的潜力,用于针对 CRC 的新疗法策略.
主要方法:
- 按照PRISMA指南进行了系统审查,搜索了七个科学数据库.
- 总共有200篇文章被选,其中24篇文章符合分析的纳入标准.
- 分析了这些已识别的物品,以确定lncRNAs与CRC中的mTOR信号通路的关联.
主要成果:
- 在CRC中,23个lncRNA被确定与mTOR信号通路有关.
- 对于大多数 (79.16%) 已识别的 lncRNAs,观察到显著的上调调节趋势.
- 相反,在优先考虑的lncRNAs的剩余20.84%中,发现了下调的趋势.
- 数据表明,特定的lncRNAs的改变可以调节mTOR通路的活动,在CRC进展过程中刺激或抑制它.
结论:
- lncRNAs的异常表达显著影响着结直肠癌中的mTOR信号通路.
- 这些mTOR相关的lncRNAs代表了CRC诊断和预后的潜在生物标志物.
- 针对 lncRNAs 和 mTOR 途径之间的动态相互作用,可能会导致结直肠癌的新型分子治疗方法的开发.
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