Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

838
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
838

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Field resistance of Phytophthora melonis to metalaxyl in South China].

Wei sheng wu xue bao = Acta microbiologica Sinica·2011
Same author

Anatomical and physiological plasticity in Leymus chinensis (Poaceae) along large-scale longitudinal gradient in northeast China.

PloS one·2011
Same author

CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling.

The Journal of biological chemistry·2011
Same author

Ultrathin platinum nanowire catalysts for direct C-N coupling of carbonyls with aromatic nitro compounds under 1 bar of hydrogen.

Chemistry (Weinheim an der Bergstrasse, Germany)·2011
Same author

{meso-Tetra-kis[p-(hept-yloxy)phen-yl]-porphyrinato}silver(II).

Acta crystallographica. Section E, Structure reports online·2011
Same author

7-Amino-4-hy-droxy-4-trifluoro-methyl-3,4-dihydro-quinolin-2(1H)-one.

Acta crystallographica. Section E, Structure reports online·2011

相关实验视频

Updated: Jul 27, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

1.1K

一个CD8的全面分析.

Liang Chen1, Yiming Weng1, Xue Cui1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

BMC bioinformatics
|June 6, 2023
PubMed
概括

这项研究确定了肺状细胞癌 (LUSC) 中 CD8+ T 细胞透相关的基因特征. 较高的CD8+T细胞密度与更好的免疫疗法反应相关,有助于预后预测.

关键词:
在 CD8+ T 细胞中.免疫治疗是一种免疫疗法.肺状细胞癌是肺的状细胞癌.预测 预后 预测 预测

更多相关视频

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

9.9K
A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
09:17

A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice

Published on: January 5, 2021

7.5K

相关实验视频

Last Updated: Jul 27, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

1.1K
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
07:17

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

9.9K
A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice
09:17

A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice

Published on: January 5, 2021

7.5K

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 基因组学就是基因组学.

背景情况:

  • 与其他非小细胞肺癌亚型相比,肺状细胞癌 (LUSC) 的预后较差.
  • CD8+ T细胞对于抗瘤免疫是至关重要的,使得它们的透模式在LUSC中具有重要意义.
  • 了解CD8+T细胞透对于改善LUSC患者的治疗结果和治疗策略至关重要.

研究的目的:

  • 在LUSC.中表征CD8+ T细胞透相关 (CTLIR) 基因特征.
  • 探索CD8+T细胞密度与LUSC患者免疫治疗反应之间的相关性.
  • 为LUSC患者开发预后基因特征和风险模型.

主要方法:

  • 多重免疫组织化学被用来评估LUSC瘤组织中的CD8+T细胞密度.
  • 分析了来自TCGA和GEO数据库的大量RNA测序数据.
  • 采用CIBERSORT算法和加权基因共同表达网络分析 (WGCNA) 来识别免疫细胞丰度和基因模块.

主要成果:

  • 更高的CD8+T细胞透密度与更好的免疫治疗反应有关.
  • 开发了一种新的CTLIR基因特征,将患者分为高风险和低风险组.
  • 高风险组的整体存活时间较短,CD8+T细胞较少,T细胞调节性较多,以及免疫抑制性瘤微环境.
  • 高风险组对PD-1和CTLA4抑制剂的预测反应更好.

结论:

  • CTLIR基因特征作为LUSC的独立预后因素.
  • 开发的风险模型可以预测LUSC患者的预后和免疫治疗反应.
  • 这项研究为LUSC的免疫格局及其对治疗的影响提供了宝贵的见解.