在埃塞俄比亚西北部冈达尔的基因X-pert结核病阴性成年患者中发现的致病细菌
Hana Yohannes1, Teshome Belachew2, Muluneh Assefa3
1Department of Immunology and Molecular biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC pulmonary medicine
|June 6, 2023
概括
埃塞俄比亚的耐药细菌导致了显著的下呼吸道感染 (LRTI). 这项研究在肺结核阴性患者中确定了常见的细菌病原体及其抗生素耐药性模式,突出了常规敏感性测试的必要性.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 耐药细菌对公众健康构成重大威胁,特别是在发展中国家.
- 下呼吸道感染 (LRTI) 是一个主要问题,通常是由具有挑战性的细菌病原体引起的.
研究的目的:
- 在基因X-pert肺结核阴性成年患者中识别导致LRTI的致病细菌.
- 为了确定这些细菌分离物的抗微生物敏感性模式.
- 为研究区域中LRTIs的治疗策略提供信息.
主要方法:
- 在冈达尔大学综合专业推医院进行了一项基于机构的横截面研究.
- 从254名结核阴性成年患者中收集了唾液样本.
- 使用标准的微生物技术进行了细菌鉴定和抗菌敏感性测试,包括Kirby-Bauer盘扩散.
主要成果:
- 唾液培养的阳性率为57.1%,其中格拉姆阴性细菌 (64.9%) 主导.
- 黄金葡萄球菌 (66.7%) 是最常见的格拉姆阳性分离物,而Klebsiella pneumoniae (29.7%) 是最常见的格拉姆阴性分离物.
- 在格拉姆阴性细菌中观察到对安皮西林的高耐药率,而S. aureus对西普罗夫洛克萨,热纳米辛,塞福西和克林达米辛表现出良好的敏感性.
结论:
- 在研究群体中,大量的格拉姆阴性和格拉姆阳性细菌病原体导致LRTIs.
- 常规的唾液培养和抗生素敏感性测试对于管理疑似LRTIs的基因X-pert结核病阴性患者至关重要.
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