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在子宫内感染/炎症引起的肺损伤中的长非编码RNA签名:一个综合生物信息学研究

Jiarong Pan¹, Canyang Zhan¹, Tianming Yuan²

¹Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310052, Zhejiang, China.

BMC pulmonary medicine

|June 6, 2023

概括

宫内感染导致胎儿和新生儿肺部损伤. 这项研究确定了新型长非编码RNA (lncRNAs) 作为这种疾病的潜在生物标志物和治疗点.

科学领域:

生殖生物学和发育毒理学.
肺部医学和重症监护
分子生物学和基因组学

背景情况:

子宫内感染/炎症是已知的胎儿和新生儿肺部损伤的原因.
将子宫内感染与肺损伤和发育问题联系起来的确切的生物机制仍然不清楚.
目前,对于宫内感染引起的肺损伤缺乏可靠的生物标志物.

研究的目的:

调查子宫内感染/炎症引起的胎儿和新生儿肺部损伤的生物机制.
为了确定潜在的诊断生物标志物和治疗点子宫内感染/炎症引起的肺损伤.

主要方法:

建立了一个动物模型,使用暴露于大肠杆菌的孕妇斯普拉格-道利大鼠.
进行了胎盘,子宫和胎儿/新生儿大鼠肺部的组织学检查.
高通量测序在肺组织中确定了差异表达的长非编码RNA (lncRNA) 和信使RNA (mRNA).

主要成果:

组织病理学揭示了炎症透,膜结构受损和受影响的肺部膜数量减少.
传输电子显微镜显示了扩散的膜损伤和表面活性剂储存层状体的减少.
全基因组测序确定了432个在胚胎第17天和125个在产后第3天以差异表达的lncRNA,其中几个特定的lncRNA与肺损伤有关.

结论:

这项研究提供了一个全面的全基因组识别与子宫内感染/炎症诱导的肺损伤相关的新 lncRNAs.
这些已识别的 lncRNAs 显示出作为潜在的诊断生物标记物的前景.
鉴定到的lncRNAs也可能作为治疗治疗子宫内感染/炎症引起的肺损伤的新治疗点.

关键词:

炎症炎症是一种炎症.在子宫内感染.长非编码RNA是什么意思肺部损伤肺部损伤肺部损伤

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