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在前列腺癌中代谢相关的分子模式的表征

Bowei Yang¹, Yongming Jiang¹, Jun Yang¹

¹Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.

|June 6, 2023

概括

这项研究将前列腺癌分为两种与代谢相关的分子亚型,确定10个基因签名,用于预测无病生存和指导治疗策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

癌症代谢对于瘤的进展和治疗耐药性至关重要.
了解新陈代谢模式可以揭示前列腺癌的新治疗点.

研究的目的:

在前列腺癌中根据与代谢相关的基因分类分子亚型.
研究这些亚型的临床,分子和瘤微环境特征.
开发一种预后签名,用于预测前列腺癌患者的无疾病生存率.

主要方法:

利用来自TCGA,cBioPortal和GEO数据库的与代谢相关的基因 (MAG) 的无监督非负矩阵因子化 (NMF) 聚类.
分析了亚群之间的无病生存 (DFS),临床病理特征,途径,瘤微环境 (TME),免疫细胞透和治疗反应的差异.
使用LASSO考克斯回归分析构建了一个预后签名,用于DFS预测.

主要成果:

在489名前列腺癌患者中确定了两个不同的与代谢相关的分子子集群.
这些子集群在临床特征 (年龄,T/N阶段,格里森得分) 和DFS方面显示出显著差异.
开发了一个10-MAG签名,创建了一个风险模型,可以在数据集中准确预测DFS,AUC值高达0.809. 高风险分数与较差的DFS相关.
风险评分和格里森评分是DFS的独立预后因素.

结论:

在前列腺癌中确定了两个不同的与代谢相关的分子子集群.
为前列腺癌的预后预测,开发了一种新的与代谢相关的风险概况.
这些发现提供了对代谢异质性和前列腺癌潜在治疗策略的见解.

关键词:

代谢过程中的代谢.分子子集群分子子集群预测预后预测预测前列腺癌是什么意思前列腺癌是什么意思瘤环境瘤环境

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