母亲微生物群和妊娠期糖尿病:对婴儿健康的影响
Parul Singh1,2, Duaa Ahmed Idris Elhaj2, Ibrahim Ibrahim3
1College of Health & Life Sciences, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Journal of translational medicine
|June 6, 2023
概括
孕期糖尿病 (GDM) 影响母亲的新陈代谢和婴儿的健康. 本综述探讨了母体微生物组如何影响GDM发育和后代的结果,并建议基于微生物群的干预措施.
科学领域:
- 生殖生物学 生殖生物学
- 代谢障碍 代谢障碍 代谢障碍
- 微生物组研究的研究.
背景情况:
- 怀孕涉及复杂的生理适应;偏差可以导致诸如妊娠期糖尿病 (GDM) 等不良结果.
- 母亲微生物组的改变与怀孕期间的代谢功能障碍有关,并影响婴儿的健康.
- 微生物代谢产物在宿主健康和代谢调节中起着至关重要的作用.
研究的目的:
- 审查母亲微生物群及其代谢物在GDM发育中的作用.
- 检查与GDM相关的微生物组变化如何影响婴儿健康.
- 讨论基于微生物群的干预措施和准确医学的未来研究方向.
主要方法:
- 关于GDM,母亲微生物组和婴儿健康的当前研究的文献综述.
- 对研究微生物代谢物及其对母亲代谢的影响的研究进行分析.
- 综合了基于微生物群的干预措施和精准医学方法的发现.
主要成果:
- 孕产妇微生物组失生症与GDM的发病有关.
- 在GDM期间,母亲肠道微生物组的变化可能会对婴儿的代谢健康和长期结果产生负面影响.
- 特定的微生物代谢物可能有助于GDM的发展和进展.
结论:
- 母亲微生物组是GDM发育及其对后代的影响的关键因素.
- 针对母亲的微生物组为GDM和相关的婴儿健康问题提供了潜在的治疗策略.
- 对基于微生物群的干预和精准医学进行进一步的研究是有必要的,以管理GDM并改善母婴健康结果.
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