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增加动脉硬与累积的并发症与心力衰竭与保存的射出分数相关
Danish Ali1, Patrick Tran2,3, Stuart Ennis1,4
1Warwick Medical School, University of Warwick, Coventry, UK.
ESC heart failure
|June 6, 2023
概括
动脉硬性随着心血管并发症在心力衰竭中增加,心脏衰竭具有保存的射出分数 (HFpEF). 脉冲波速度 (PWV) 可以识别HFpEF前的阶段,为早期干预提供临床工具.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 心脏衰竭研究研究
背景情况:
- 心力衰竭与保存的喷射分数 (HFpEF) 病理生理学涉及宏血管功能障碍和改变的心室血管合.
- 在HFpEF中,并发症和动脉硬的具体作用尚未完全理解.
- 衰老和累积的心血管并发症可能会逐渐增加动脉硬.
研究的目的:
- 在HFpEF中调查心血管并发症和动脉硬之间的关系.
- 为了确定HFpEF之前是否有累积增加的动脉硬度超出了与年龄相关的变化.
- 探索动脉刚性的潜力,作为早期HFpEF检测的生物标志物.
主要方法:
- 在五组中使用脉冲波速度 (PWV) 评估动脉硬性:健康志愿者,高血压,糖尿病高血压,HFpEF和心力衰竭减少射出分数 (HFrEF).
- 所有参与者都是70岁及以上的.
- 分析了与年龄,并发症和心声学参数相关的PWV.
主要成果:
- 平均PWV随着血管并发症 (高血压,糖尿病) 逐渐增加,独立于其他因素.
- HFpEF组表现出最高的PWV,而HFrEF显示出接近正常的水平.
- PWV与峰值氧气消耗相反,与左心室填充压力正相关.
结论:
- HFpEF的特点是动脉硬度增加,由血管衰老和诸如高血压和糖尿病等并发症驱动.
- 脉冲波速率 (PWV) 可以作为动脉后负荷,腹筋功能障碍和运动能力的临床指标.
- 在明显的疾病表现之前,PWV可能是识别有HFpEF前表型风险的个体的宝贵工具.
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