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在TNFα/IFNγ诱导的HaCaT皮细胞和TNFα/IFNγ诱导的HaCaT皮细胞中的抗炎反应和益生菌性质

Ji Yeon Lee¹, Jeong-Yong Park¹, Yulah Jeong¹

¹Mediogen Co., Ltd., Jecheon 27159, Republic of Korea.

Journal of microbiology and biotechnology

|June 7, 2023

概括

乳酸细菌 (LAB) 的置物显示在亚托皮性皮炎 (AD) 模型上具有抗炎作用. 特定的LAB菌株是安全和稳定的,表明功能性食品有潜力改善AD.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
皮肤病学皮肤病学

背景情况:

亚托皮炎 (AD) 是一种由免疫失调驱动的慢性炎症性皮肤疾病.
乳酸细菌 (LAB) 超 (SL) 具有抗炎性质.
刺激TNF-α/IFN-γ的HaCaT角质细胞模拟了类似AD的反应.

研究的目的:

评估LAB SL对HaCaT角质细胞的抗炎作用.
调查选定的LAB菌株的益生菌特性.
评估LAB在AD管理中的功能性食品应用的潜力.

主要方法:

使用LAB SL.治疗TNF-α/IFN-γ诱导的HaCaT细胞.
对化学和细胞调节的分析 (MDC,TARC,IL-4,IL-5,IL-25,IL-33). 这项研究涉及:
对NF-κB和MAPK信号通路的评估.
评估LAB菌株的安全性 (血液溶解,BSH活性,毒性) 和稳定性.

主要成果:

实验室SL证明了非细胞毒性作用.
SL调节了参与AD的关键化学因子和细胞因子.
SL降低了NF-κB和MAPK的酸化.
精选的LAB菌株 (L. rhamnosus MG4644,L. paracasei MG4693,Lc. paracasei MG4693,Lc. 乳糖MG5474) 是安全,稳定和有效的.

结论:

拉布·斯拉尔 (LAB SL) 具有显著的抗炎潜力,可以对抗AD类反应.
L. rhamnosus MG4644,L. paracasei MG4693,以及Lc. 这两种类型的植物都存在. 乳糖MG5474是功能性食品的有希望的候选人.
这些LAB菌株提供了一种安全而稳定的方法,以潜在地改善亚托皮性炎症.

关键词:

这是抗炎药物.没有细胞的超浮体.角质细胞 (keratinocytes) 是一种细胞.乳酸细菌是一种乳酸细菌.益生菌是一种益生菌.

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