在Dictyostelium discoideum的发展过程中细胞循环的进展及其与随后在多细胞结构中的细胞分类的关系
1Biological Institute, Faculty of Science, Tohoku University, Aoba, Sendai 980-77, Japan.
Development, growth & differentiation
|June 7, 2023
概括
饥饿后的细胞循环进展影响Dictyostelium的发育. 在不同细胞周期阶段进入饥饿的细胞表现出不同的发育行为,影响细胞分类和分化.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 生物化学 生物化学
背景情况:
- 饥饿开始时的细胞周期阶段是Dictyostelium发育中的一个已知的变量.
- 这个变量影响了随后的细胞分类和分化过程.
研究的目的:
- 分析Dictyostelium discoideum Ax-2细胞在发育过程中的细胞周期进展.
- 研究细胞循环进展和随后的细胞分类之间的关系.
主要方法:
- 使用了同步的Dictyostelium discoideum Ax-2细胞.使用了同步的Dictyostelium discoideum Ax-2细胞.
- 用5'-氧氨 (BrdU) 进行脉冲标记,用于细胞跟踪.
- 测量细胞数量和核度,以评估细胞循环的进展.
主要成果:
- 大约80%的细胞在多细胞形成后通过细胞循环.
- 在中后G2阶段 (T7细胞) 饥饿的细胞继续通过细胞周期后形成.
- 在G2阶段晚期饥饿的细胞 (T1细胞) 在堆形成后显示出有限的细胞循环进展.
结论:
- 饥饿后的细胞循环进展是Dictyostelium发育的关键因素.
- 与细胞周期相比,饥饿的时间影响细胞分化和模式形成.
相关概念视频
Diversity of Protists IV
49
Amoebozoa represent a diverse group of terrestrial and aquatic protists that utilize lobe-shaped pseudopodia for locomotion and feeding. This characteristic differentiates them from the Rhizaria, which possess threadlike pseudopodia. The primary classifications within Amoebozoa include gymnamoebas, entamoebas, and the plasmodial and cellular slime molds. Phylogenetic evidence indicates that Amoebozoa diverged from a lineage that ultimately gave rise to fungi and animals.Gymnamoebas and...
49
Cells Coordinate Growth and Proliferation
4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K
Determining the Plane of Cell Division
3.4K
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division...
3.4K
The Cell Cycle Control System
3.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.1K
Distribution of Cytoplasmic Content
4.2K
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of...
4.2K
Centrioles and Centrosomes
2.8K
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or...
Near the end of the prophase, also called late prophase or...
2.8K


