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Updated: Aug 9, 2026

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细胞分类和在肢体芽重组物和培养物中基聚合物的形成: (细胞分类/细胞聚合物/小子肢体芽/近距离轴/基生成)

Naoyuki Wada1, Kohji Uchiyama1, Hiroyuki Ide1

  • 1Biological Institute, Tohoku University, Sendai, Japan.

Development, growth & differentiation
|June 7, 2023
PubMed
概括

在发育过程中,小肢芽的进步区 (PZ) 中的细胞特性发生变化. 早期进化区细胞在整个四肢中形成软骨,而晚期进化区细胞只形成远端软骨.

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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...