细胞结合模式在聚合物中由多个细胞-细胞粘附机制控制
Tadao Atsumi1, Masatoshi Takeichi1
1Department of Biophysics, Faculty of Science, University of Kyoto, Kyoto 606, Japan.
Development, growth & differentiation
|June 7, 2023
概括
在中国仓鼠V79细胞中,有两种不同的细胞粘附机制影响聚合结构. 取决于的机制促进紧密的结点和棒状的形状,而取决于的机制导致松散的附件和球状的形状.
科学领域:
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 中国仓鼠V79细胞表现出两个主要的聚合机制:依赖和独立于.
- 了解这些机制在聚合物形成中的不同作用对于细胞生物学研究至关重要.
研究的目的:
- 研究依赖和依赖的细胞粘附机制对V79细胞聚合物的形态的差异性贡献.
- 阐明这两种机制如何影响细胞间相互作用和聚合结构.
主要方法:
- 使用光和电子显微镜对V79细胞聚合物的比较分析.
- 对具有不同聚合性质的V79细胞克隆进行隔离和表征.
- 微观检查由选择性激活的依赖或独立机制形成的细胞聚合物.
主要成果:
- 取决于的粘附导致细胞紧密地附着,形成间隙和中间接口,以及杆状或树突状聚合体形状.
- 不依赖的粘附导致了细胞松的附着,缺乏专门的结点,以及球状聚合物形状.
- V79细胞克隆在软菌群中表现出形态差异,这种差异归因于独立粘附机制活动的变化.
结论:
- 取决于的粘附机制和独立于的粘附机制在确定V79细胞聚合物的排列和形态方面发挥着不同的和互补的作用.
- 独立机制的活性是区分V79细胞克隆在殖民地形态学方面的一个关键因素.
相关概念视频
Cell Adhesion Molecules - Types and Functions
6.9K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...
CAM Families
The Integrin family of proteins is primarily involved...
6.9K
Adherens Junctions
4.9K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
4.9K
Cell Adhesion in Plants
2.8K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
2.8K
Overview of Cell-Matrix Interactions
7.3K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.3K
Intracellular Signaling Affects Focal Adhesions
2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.7K
Anchoring Junctions
3.8K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.8K


