在健康和住院的狗中,总血清和电离的度
Megan E Murray1, Ludivine Boiron1, Yekaterina Buriko1
1School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
概括
电离 (iMg) 和总 (tMg) 在狗中存在联系,但这种联系在住院动物中减弱. 这一发现质疑iMg和tMg的可互换使用,用于监测患病狗的状况.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 临床病理学 临床病理学
- 狗的健康 狗的健康
背景情况:
- 对于生理功能至关重要.
- 了解的状况对于诊断和管理狗的健康状况至关重要.
- 电离 (iMg) 代表生物活性形式,而总 (tMg) 包括蛋白质结合和复杂形式.
研究的目的:
- 在健康和住院的狗中研究电离 (iMg) 和总 (tMg) 之间的关联.
- 评估iMg和tMg与总蛋白质,白蛋白,电离和总的关系.
- 评估在临床环境中互换使用iMg和tMg的可靠性.
主要方法:
- 未来的队列研究涉及69只狗在一个兽医教学医院.
- 狗被分为一个健康的对照组 (n=24) 和一个住院的组 (n=45).
- 在任何干预之前都进行了静脉血液气体和血清生物化学分析.
主要成果:
- 在健康的 (r=0.6713,P=0.0003) 和住院的狗 (r=0.5312,P=0.0002) 中观察到iMg和tMg之间的显著正相关性.
- 住院的狗表现出Img水平低于健康组的范围.
- 没有发现iMg/tMg与总蛋白,白蛋白,电离或总之间有显著的关联.
结论:
- 电离和总在健康和住院的狗中都有显著的相关性.
- 与健康狗相比,住院狗的IMg和tMg之间的相关性较弱.
- 住院狗的较弱关联引起了人们对使用iMg和tMg互换用于监测状况的有效性表示担忧.
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