在患有糖尿病的孕妇中预测子前期的预测
Ashok Kumar1, Perumal Vanamail2, Ram Kumar Gupta1
1Department of 1Obstetrics & Gynaecology, Maulana Azad Medical College & Lok Nayak Hospital, New Delhi, India.
The Indian journal of medical research
|June 7, 2023
概括
患有糖尿病的孕妇,包括妊娠期糖尿病 (GDM) 和先前存在的糖尿病 (DM),面临着明显更高的患有先兆子的风险. 确定的关键风险因素包括社会经济地位,先前的孕前和先前存在的糖尿病.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 糖尿病类 (DM) 和妊娠期糖尿病类 (GDM) 是已知的妊娠前的危险因素.
- 糖尿病怀孕中的孕前与增加的孕产妇和胎儿并发症有关.
研究的目的:
- 调查患有DM/GDM的孕妇中产前的临床风险因素.
- 评估怀孕早期的生化标志物,以预测这一群体的先兆子.
主要方法:
- 一项病例对照研究,将患有DM/GDM的孕妇与健康对照进行比较.
- 评估性激素结合型全球蛋白 (SHBG),胰岛素样生长因子-I (IGF-I) 和25-氧维生素D[25(OH) D]水平以及基因多态性.
主要成果:
- 与对照组 (13.92%) 相比,患有DM/GDM的女性患有妊娠前的发病率更高 (30.38%).
- 更高的社会经济地位,先前存在的DM和先前的子宫前是显著的危险因素.
- 血清生物标志物 (SHBG,IGF-I,25(OH) D) 在患有GDM的女性中没有有效预测妊娠前.
结论:
- 患有糖尿病的孕妇有高患子宫前的风险.
- 社会经济地位,先前的子前期和先前存在的糖尿病是关键的风险因素.
- 评估的生物标志物水平在这个人群中无法预测子宫前.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
Diabetes: Symptoms, Diagnosis, and Complications
605
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
605
Dipeptidyl Peptidase 4 Inhibitors
216
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
216
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K


