乳腺癌幸存者的荷尔蒙特征与疲劳:一个试点研究
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Shardool Vikram Gupta1, Navneet Kaur2, S V Madhu3
1Department of Surgery, Dr BSA Medical College & Hospital, New Delhi, India.
The Indian journal of medical research
|June 7, 2023
概括
荷尔蒙失衡,特别是甲状腺荷尔蒙和脱氨二硫酸 (DHEAS),可能导致乳腺癌幸存者的癌症相关疲劳 (CRF). 需要进一步的研究来探索这些联系.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 癌症的生存率 癌症的生存率
背景情况:
- 与癌症相关的疲劳 (CRF) 是乳腺癌幸存者 (BCS) 中的一个普遍问题.
- 荷尔蒙失调在CRF病因中的作用仍未得到充分研究.
- 这项试点研究解决了了解BCS中荷尔蒙对疲劳的影响的差距.
研究的目的:
- 研究乳腺癌幸存者的疲劳和激素水平之间的联系.
- 为了评估甲状腺激素水平,皮质醇,脱氨硫酸 (DHEAS),雌激素和孕在疲劳的BCS中.
主要方法:
- 一项试点研究涉及110名乳腺癌幸存者报告疲劳.
- 使用简要疲劳清单 (BFI) 评估疲劳严重程度.
- 在中度至重度疲劳的幸存者中评估激素配置 (甲状腺,皮质醇,DHEAS,雌激素,孕激素).
主要成果:
- 56%的幸存者经历了中度至严重的疲劳.
- 在35.48%的参与者中观察到甲状腺功能障碍.
- 甲状腺刺激激素 (TSH) 与疲劳严重程度有显著的负面关联 (P<0.05).
- 在19.35%的幸存者中发现了降低的DHEAS水平.
- 在35.48%的绝经后幸存者中发现雌激素水平升高.
结论:
- 激素因素,特别是甲状腺激素和DHEAS,可能在BCS患者经历的CRF中发挥重要作用.
- 这些发现需要进一步研究荷尔蒙环境及其对癌症相关疲劳的影响.
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