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雌醇调节雌性小鼠对急性和恒定的光照暴露的循环反应

Julie M Michaud¹, Caitlin T Waring¹, Fernanda Medeiros Contini¹

¹Department of Biological Sciences, Bridgewater State University, Bridgewater, Massachusetts.

Journal of biological rhythms

|June 7, 2023

概括

雌醇对于维持昼夜节律的强度和对光的反应至关重要. 在卵巢切除的小鼠中,激素替代恢复了昼夜活动,并保护它们免受光引起的干扰.

科学领域:

时间生物学时间生物学
神经内分泌学神经内分泌学
循环节律是指循环节律的节奏.

背景情况:

性激素,特别是雌激素,是已知的昼夜计时的调节者.
淋巴切除术破坏昼夜节律和对光的反应,影响上神经核 (SCN).
雌激醇在调解这些光诱导的昼夜反应中的特定作用需要进一步研究.

研究的目的:

调查雌性小鼠对急性和慢性光暴露的昼夜反应调节中的雌性醇的作用.
为了确定雌激醇替代是否可以减轻卵巢切除术对昼夜节律和光敏度的影响.

主要方法:

使用了经过卵巢切除 (OVX) 和假手术的C57BL6/NJ雌性小鼠.
用雌激素 (E) 或安慰剂 (P) 颗粒进行激素替代治疗.
在65天的时间里,小鼠接受了标准光:暗光 (LD) 或恒光 (LL).
评估了循环节,节律强度,运动运动活动和对光脉冲的反应.
测量了血清雌激醇和SCN雌激醇受体α (ERα) 和β (ERβ) 的水平.

主要成果:

与没有雌激素的卵巢切除小鼠 (OVX+P) 相比,与没有雌激素的小鼠相比,在恒定的光线下 (LL) 呈现较短的昼夜周期和更高的节律失常.
在LD和LL条件下,雌激素缺乏的小鼠表现出降低的昼夜强度和运动运动活动.
雌激素替代剂 (OVX+E) 恢复了昼夜强度和活动水平,并减弱了光脉冲的相位延迟.
持续暴露于光线会降低ERβ水平,但不会降低ERα,无论手术治疗如何.

结论:

雌激醇在调节昼夜系统对光的反应方面发挥着重要作用.
雌激醇增强昼夜强度,并保护免受持续暴露于光线所引起的干扰.
雌激醇替代疗法可以恢复正常的昼夜功能,并改善被卵巢切除的女性对光的反应.

关键词:

17β-雌二醇是17β-雌二醇中的一种.昼夜节律昼夜节律恒定的光线恒定的光线雌激素受体的受体是雌激素受体.卵巢切除的小鼠

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