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Meizhi Du¹, Yu Wang¹, Jillian Vallis²

¹Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.

Cancer biology & medicine

|June 7, 2023

概括

素 (LEP) 和其受体 (LEPR) 的遗传变异影响结直肠癌 (CRC) 的存活率. 这些关联受到饮食和体重指数 (BMI) 的影响,这表明对CRC患者结果的个性化方法.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
流行病学流行病学

背景情况:

莱普 (LEP) 是一种与肥胖和瘤生长相关的阿迪波金.
在LEP及其受体 (LEPR) 的遗传变异可能会影响癌症的发展和进展.

研究的目的:

研究LEP和LEPR的遗传变异与结直肠癌 (CRC) 患者的生存结果之间的关联.
探索这些遗传变异,生活方式因素 (红肉摄入量) 和身体质量指数 (BMI) 之间的潜在相互作用.

主要方法:

分析了来自532名CRC患者的LEP和LEPR基因中的35个标签单核酸多态 (SNP).
利用多变量Cox模型来评估与整体存活率 (OS),无病存活率 (DFS) 和CRC特定存活率的关联.
检查了基因水平,单个SNP和哈普类型的关联,以及基因与环境的相互作用.

主要成果:

LEP基因变异与DFS有关,LEPR变异与DFS和CRC特异性存活率有关.
特定的LEP和LEPRSNP和类型表现出与延长的OS和DFS的关联.
莱普尔变种,红肉摄入量和BMI (<25 kg/m2) 之间的相互作用与改善的DFS有关.

结论:

在LEP和LEPR基因中的多态性与CRC患者的存活率有关.
LEP/LEPR变异对CRC存活率的影响受到红肉消费和BMI的改变.
研究结果表明,遗传和生活方式因素在CRC预后中可能发挥作用.

关键词:

大肠直肠癌的生存率基因与环境的相互作用.多形态主义的多态主义.

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